LMPD Database

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LMP008787

UniProt Annotations

Entry Information
Gene NameCG32699 gene product from transcript CG32699-RB
Protein EntryQ0KHU5_DROME
UniProt IDQ0KHU5
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=B ; IsoId=Q0KHU5-1; Sequence=Displayed; Note=No experimental confirmation available. ; Name=A ; IsoId=Q0KHU5-2; Sequence=VSP_052338; Note=No experimental confirmation available. ;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
FunctionAcetyltransferase which mediates the conversion of 1- acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Has a calcium-independent activity. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1- palmitoyl LPC as acyl donors and acceptors, respectively (By similarity).
PathwayLipid metabolism; phospholipid metabolism.
Rna EditingModified_positions=175 {ECO:0000269|PubMed:17018572, ECO:0000269|Ref.3}; Note=Partially edited. Target of Adar. ;
Sequence CautionSequence=AAL28380.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SimilarityContains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane ; Single-pass type II membrane protein .