LMPD Database

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LMP008789

UniProt Annotations

Entry Information
Gene NamePhospholipase C at 21C
Protein EntryPIP1_DROME
UniProt IDP25455
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=D; IsoId=P25455-3; Sequence=Displayed; Note=No experimental confirmation available.; Name=1; Synonyms=Class-I; IsoId=P25455-2; Sequence=VSP_021970, VSP_004727; Name=A; Synonyms=B, Class-II; IsoId=P25455-1; Sequence=VSP_021970; Name=C; IsoId=P25455-4; Sequence=VSP_004727; Note=No experimental confirmation available.; Name=H; IsoId=P25455-5; Sequence=VSP_053950, VSP_004727; Note=No experimental confirmation available.; Name=G; IsoId=P25455-6; Sequence=VSP_053949, VSP_004727; Note=No experimental confirmation available.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Tissue SpecificityExpressed in neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia in adults, and the brain of larvae. {ECO:0000269|PubMed:2061323}.