LMPD Database

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LMP008862

UniProt Annotations

Entry Information
Gene NamePeroxinectin-like
Protein EntryQ9VEG6_DROME
UniProt IDQ9VEG6
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic Activity2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
CofactorName=heme b; Xref=ChEBI:CHEBI:60344; Evidence= ; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per heterodimer. ;
Developmental StageExpressed both maternally and zygotically.
Disruption PhenotypeFemales are sterile, and maturing follicles show defects in actin filament formation, nurse cell membrane stability and border cell migration.
FunctionRequired for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.
Sequence CautionSequence=AAF78217.1; Type=Erroneous termination; Positions=810; Note=Translated as stop.; Evidence= ; Sequence=AAF78217.1; Type=Frameshift; Positions=220, 233, 238, 244, 331, 336, 381, 384, 644, 688; Evidence= ;
SimilarityBelongs to the peroxidase family. XPO subfamily.
Subcellular LocationSecreted . Note=In the chorion layer of the mature eggs.
SubunitHeterodimer.
Tissue SpecificityExpressed at low levels in the germarium and early follicles. Expression becomes progressively stronger during vitellogenesis, and is highly expressed in germ cells and somatic cells. A subset of follicle cells, termed border cells (BC), exhibit a high level of expression.