LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP008885

UniProt Annotations

Entry Information
Gene NameDiacyl glycerol kinase
Protein EntryDGK1_DROME
UniProt ID
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=E; IsoId=Q01583-4; Sequence=Displayed; Note=No experimental confirmation available.; Name=C; IsoId=Q01583-3; Sequence=VSP_017884; Name=F; IsoId=Q01583-1; Sequence=VSP_033247; Note=No experimental confirmation available.; Name=G; IsoId=Q01583-2; Sequence=VSP_017885, VSP_017886, VSP_017887;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Developmental StageExpressed in the embryonic, pupal and adult stages, with little expression during the larval stages. {ECO:0000269|PubMed:1321433, ECO:0000269|PubMed:8380995}.
FunctionUpon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons. {ECO:0000250, ECO:0000269|PubMed:1321433, ECO:0000269|PubMed:8380995}.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Tissue SpecificityIn 10-11 hours embryos, expression is abundant in a limited number of cells in the procephalic region and in the ventral nerve cord. Predominantly expressed in the adult nervous system and muscle: including compound eyes, brain cortex, fibrillar muscle, and tubular muscle. {ECO:0000269|PubMed:1321433, ECO:0000269|PubMed:8380995}.