LMPD Database

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LMP009032

UniProt Annotations

Entry Information
Gene Namenessy
Protein EntryQ9VVX5_DROME
UniProt IDQ9VVX5
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
CautionAlthough strongly related to the membrane-bound acyltransferase family, it lacks the conserved His active site which is replaced by an Asn-415 residue.
Developmental StageExpressed throughout development with highest levels in adult females and preblastoderm embryos.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn- glycero-3-phosphoethanolamine or LPE) to phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1- acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has a preference for unsaturated fatty acids such as arachidonic acid.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityDuring gastrulation, expressed mainly along the midline in the presumptive mesoderm. During germ band elongation, expressed in mesoderm and endoderm primordia and in the cephalic furrow. Expression in mesoderm and endoderm lineages continues during germ band shortening. At the end of this process, no longer detected in somatic mesoderm or endoderm layer with expression restricted to anterior and posterior domains of the visceral mesoderm.