LMPD Database

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LMP009135

UniProt Annotations

Entry Information
Gene Namepatched
Protein EntryPTC_DROME
UniProt IDP18502
SpeciesDrosophila
Comments
Comment typeDescription
FunctionSegmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
SimilarityBelongs to the patched family. {ECO:0000305}.
SimilarityContains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular LocationMembrane; Multi-pass membrane protein.