LMPD Database

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LMP009142

UniProt Annotations

Entry Information
Gene Nametailless
Protein EntryTLL_DROME
UniProt IDP18102
SpeciesDrosophila
Comments
Comment typeDescription
Developmental StageDuring stage 10 found in the anterior part of the visual system that later gives rise to the anterior lip of the optic lobe. At stage 12 also found in the posterior lip of the optic lobe. In third larval instar expressed in the optic lobe of the larval brain and in the eye antennal disk, both in antennal and eye portion. {ECO:0000269|PubMed:2364433}.
FunctionOrphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. {ECO:0000269|PubMed:10357938, ECO:0000269|PubMed:2364433}.
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityBrain and peripheral nervous system. {ECO:0000269|PubMed:2364433}.