LMPD Database

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LMP009177

UniProt Annotations

Entry Information
Gene NameCG32380 gene product from transcript CG32380-RA
Protein EntryQ9VS60_DROME
UniProt IDQ9VS60
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A ; IsoId=Q9VS60-1; Sequence=Displayed; Note=No experimental confirmation available. ; Name=B ; IsoId=Q9VS60-2; Sequence=VSP_050675; Note=No experimental confirmation available. ;
DomainThe SAM domain is required to retain SMSR in the endoplasmic reticulum.
FunctionSphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
SimilarityBelongs to the sphingomyelin synthase family.
SimilarityContains 1 SAM (sterile alpha motif) domain.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .