LMPD Database

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LMP009181

UniProt Annotations

Entry Information
Gene NameSynaptotagmin 1
Protein EntrySY65_DROME
UniProt IDX2J979
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=A; IsoId=P21521-1; Sequence=Displayed; Name=B; Synonyms=C, I; IsoId=P21521-2; Sequence=VSP_011862; Note=No experimental confirmation available.; Name=E; IsoId=P21521-4; Sequence=VSP_054631; Note=No experimental confirmation available.; Name=G; IsoId=P21521-5; Sequence=VSP_054630, VSP_054632; Note=No experimental confirmation available.; Name=F; IsoId=P21521-6; Sequence=VSP_054628, VSP_054629; Note=No experimental confirmation available.;
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. {ECO:0000269|PubMed:1840599}.
InteractionQ24211:stnA; NbExp=2; IntAct=EBI-484504, EBI-604915; Q24212:stnB; NbExp=5; IntAct=EBI-484504, EBI-604879;
Rna EditingModified_positions=367 {ECO:0000269|PubMed:12907802, ECO:0000269|Ref.4}, 379 {ECO:0000269|PubMed:12907802}, 383 {ECO:0000269|PubMed:10731132, ECO:0000269|PubMed:12907802}, 405 {ECO:0000269|PubMed:10731132, ECO:0000269|PubMed:12907802}; Note=Partially edited.;
Sequence CautionSequence=AAM50109.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAM50109.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
SimilarityBelongs to the synaptotagmin family. {ECO:0000305}.
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:1840599}; Single- pass membrane protein {ECO:0000269|PubMed:1840599}. Cell junction, synapse {ECO:0000269|PubMed:1840599}. Note=Synaptic vesicles in neurons.
SubunitHomodimer or homotrimer (Potential). Interacts with StnA and StnB via its second C2 domain. This interaction may mediate its retrieval from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane. {ECO:0000269|PubMed:11069931, ECO:0000305}.