LMPD Database

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LMP009187

UniProt Annotations

Entry Information
Gene Nameheixuedian
Protein EntryUBIA1_DROME
UniProt IDQ9V3R8
SpeciesDrosophila
Comments
Comment typeDescription
FunctionPrenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption. {ECO:0000269|PubMed:22582012}.
PathwayQuinol/quinone metabolism; menaquinone biosynthesis.
SimilarityBelongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane {ECO:0000269|PubMed:22582012}; Multi-pass membrane protein {ECO:0000269|PubMed:22582012}.