LMPD Database

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LMP009191

UniProt Annotations

Entry Information
Gene Namerosy
Protein EntryXDH_DROME
UniProt IDP10351
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic ActivityHypoxanthine + NAD(+) + H(2)O = xanthine + NADH.
Catalytic ActivityXanthine + NAD(+) + H(2)O = urate + NADH.
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 2 [2Fe-2S] clusters. {ECO:0000250};
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CofactorName=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence={ECO:0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. {ECO:0000250};
FunctionKey enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAM11042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the xanthine dehydrogenase family. {ECO:0000305}.
SimilarityContains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
SimilarityContains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}.
Subcellular LocationPeroxisome {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.