LMPD Database

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LMP009653

UniProt Annotations

Entry Information
Gene Name1-acyl-sn-glycerol-3-phosphate acyltransferase 1
Protein EntryLPAT1_ARATH
UniProt IDQ8GXU8
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8GXU8-1; Sequence=Displayed; Name=2; IsoId=Q8GXU8-2; Sequence=VSP_013594; Note=No experimental confirmation available.;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed:14976237, ECO:0000269|PubMed:15169931}.
Developmental StageExpression transiently increases in siliques 4 hours after flowering. {ECO:0000269|PubMed:15169931}.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
FunctionConverts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C-16-CoA substrates compared to C-18-CoA substrates. Essential for embryo development during the transition from the globular to the heart stage when chloroplasts begin to form. {ECO:0000269|PubMed:14976237, ECO:0000269|PubMed:15169931}.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast membrane {ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:15169931}; Multi- pass membrane protein {ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:15169931}.
Tissue SpecificityWidely expressed. Expressed at higher level in leaves. Expressed at lower level in silique walls compared to leaves. {ECO:0000269|PubMed:14976237, ECO:0000269|PubMed:15169931}.