LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP009669

UniProt Annotations

Entry Information
Gene Name2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Protein EntryISPF_ARATH
UniProt IDQ9CAK8
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CAK8-1; Sequence=Displayed; Name=2; IsoId=Q9CAK8-2; Sequence=VSP_009112; Note=May be due to a competing acceptor splice site. No experimental confirmation available.;
Catalytic Activity2-phospho-4-(cytidine 5'-diphospho)-2-C- methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP.
CofactorName=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:17660251}; Note=Binds 1 divalent metal cation per subunit. {ECO:0000269|PubMed:17660251};
Disruption PhenotypeAlbino phenotype and seedling lethal when homozygous. The phenotype is caused by an early arrest in chloroplast differentiation. {ECO:0000269|PubMed:16231155}.
FunctionEnzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C- methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4- cyclodiphosphate and CMP. Also converts 4-diphosphocytidyl-2C- methyl-D-erythritol into 2C-methyl-D-erythritol 3,4-cyclophosphate and CMP. Is essential for chloroplast development. {ECO:0000269|PubMed:16231155}.
InductionCircadian-regulated with a peak in the late period of dark phase and early period of the light phase. {ECO:0000269|PubMed:15863698}.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate: step 4/6.
Sequence CautionSequence=AAF24570.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the IspF family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast stroma {ECO:0000305|PubMed:18236010}.
SubunitHomotrimer. {ECO:0000269|PubMed:17660251}.