LMPD Database

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LMP009675

UniProt Annotations

Entry Information
Gene Namethiamin diphosphate-binding fold protein
Protein EntryODBA1_ARATH
UniProt IDQ9LPL5
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase] S-(2- methylpropanoyl)dihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
FunctionThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required during sugar starvation. {ECO:0000250, ECO:0000269|PubMed:11418132}.
InductionBy dark treatment. Down-regulated by sucrose in a hexokinase dependent manner. Up-regulated by Leucine and its derivative alpha-keto acid (KIC). {ECO:0000269|PubMed:11418132}.
MiscellaneousBound potassium ions stabilize the protein structure. {ECO:0000250}.
SimilarityBelongs to the BCKDHA family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHeterotetramer of alpha and beta chains. {ECO:0000250}.