LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP009678

UniProt Annotations

Entry Information
Gene Namebranched chain alpha-keto acid dehydrogenase E1 beta
Protein EntryODBB2_ARATH
UniProt IDQ9LDY2
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase] S-(2- methylpropanoyl)dihydrolipoyllysine + CO(2).
Developmental StageBarely detected in non senescent green leaves, accumulated slightly at the early stage of leaf senescence and strongly expressed at the late stage of leaf senescence. {ECO:0000269|PubMed:10681595}.
FunctionThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required during sugar starvation and acts under the control of a sugar-sensing mechanism involving Ser/Thr kinases and phosphatases. {ECO:0000250, ECO:0000269|PubMed:11080291, ECO:0000269|PubMed:11917081}.
InductionBy dark treatment. Down-regulated by sucrose in a hexokinase dependent manner. Up-regulated by Leucine and its derivative alpha-keto acid (KIC). {ECO:0000269|PubMed:10681595, ECO:0000269|PubMed:11080291, ECO:0000269|PubMed:11418132, ECO:0000269|PubMed:11917081}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHeterotetramer of alpha and beta chains. {ECO:0000250}.
Tissue SpecificityExpressed in the non-photosynthetic organs such as siliques, flowers and roots. {ECO:0000269|PubMed:10681595}.