LMPD Database

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LMP009681

UniProt Annotations

Entry Information
Gene Name3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
Protein EntryHSDD1_ARATH
UniProt IDQ9FX01
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9FX01-1; Sequence=Displayed; Name=2; IsoId=Q9FX01-2; Sequence=VSP_037002; Note=May be due to a competing acceptor splice site. No experimental confirmation available. Ref.1 (AAY28502) and Ref.6 (AAM62504) sequences differ from that shown due to erroneous initiation (Translation N-terminally extended). {ECO:0000305};
Catalytic ActivityA 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
CautionLacks one transmembrane, which is a conserved feature of the family. {ECO:0000305}.
DomainThe RETICULON domain is partial in comparison with the other paralogs.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
Sequence CautionSequence=AAM62504.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY28502.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the 3-beta-HSD family. {ECO:0000305}.
SimilarityContains 1 reticulon domain. {ECO:0000255|PROSITE- ProRule:PRU00170}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.