LMPD Database

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LMP009688

UniProt Annotations

Entry Information
Gene Name3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Protein EntryHMDH2_ARATH
UniProt IDP43256
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity(R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH. {ECO:0000255|PROSITE- ProRule:PRU10003}.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but 25% lower levels in triterpenoids content and 15% lower levels in sterol content. Hmg1 and hmg2 double mutants are lethal during male gametophyte development. {ECO:0000269|PubMed:14871314, ECO:0000269|PubMed:17917299, ECO:0000269|PubMed:19363204}.
Enzyme RegulationRegulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways. {ECO:0000269|PubMed:19041104}.
FunctionCatalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants. {ECO:0000269|PubMed:14871314, ECO:0000269|PubMed:17917299, ECO:0000269|PubMed:19041104, ECO:0000269|PubMed:19363204}.
InductionNot regulated by myriocin, squalestatin or terbinafine. {ECO:0000269|PubMed:19041104}.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
SimilarityBelongs to the HMG-CoA reductase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:8302869}; Multi-pass membrane protein {ECO:0000269|PubMed:8302869}.
Tissue SpecificityRestricted to young seedlings, roots, and inflorescences. Expressed in root tips, shoot apex, secretory zone of the stigma, microspores, mature pollen grains, gynoecium vascular tissue and fertilized ovules. {ECO:0000269|PubMed:19363204, ECO:0000269|PubMed:7780305, ECO:0000269|PubMed:8302869}.