LMPD Database

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LMP009755

UniProt Annotations

Entry Information
Gene Nameacetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Protein EntryACCA_ARATH
UniProt IDQ9LD43
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
FunctionComponent of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity). {ECO:0000250}.
PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
SimilarityBelongs to the AccA family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast inner membrane {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}; Peripheral membrane protein {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}; Stromal side {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}.
SubunitAcetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD). {ECO:0000269|PubMed:10759501}.
Tissue SpecificityAccumulates in fatty acids synthesizing tissues such as embryos, expanding leaves, flower buds, flowers, and developing siliques. {ECO:0000269|PubMed:10759501}.