LMPD Database

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LMP009863

UniProt Annotations

Entry Information
Gene NameAP-2 complex subunit alpha-2
Protein EntryAP2A2_ARATH
UniProt IDQ8LPK4
SpeciesArabidopsis
Comments
Comment typeDescription
FunctionSubunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides. {ECO:0000269|PubMed:15054111}.
InteractionQ9ZVN6:AP180; NbExp=2; IntAct=EBI-2366827, EBI-2366853;
Sequence CautionSequence=BAB10137.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the adaptor complexes large subunit family. {ECO:0000305}.
SimilarityContains 1 GAE domain. {ECO:0000305}.
SimilarityContains 4 HEAT repeats. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15574830, ECO:0000269|PubMed:17644812}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
SubunitAdaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit) (By similarity). Interacts with AP180. {ECO:0000250, ECO:0000269|PubMed:15054111}.