LMPD Database

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LMP009899

UniProt Annotations

Entry Information
Gene NameBAX inhibitor 1
Protein EntryBI1_ARATH
UniProt IDQ9LD45
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeNo visible phenotype under normal growth conditions. Accelerated methyl jasmonate-induced leaf senescence. Enhanced sensitivity to water stress, heat shock, toxin, tunicamycin and pathogens. {ECO:0000269|PubMed:16507080, ECO:0000269|PubMed:18039663, ECO:0000269|PubMed:19674971, ECO:0000269|PubMed:20298483, ECO:0000269|PubMed:22563118}.
FunctionSuppressor of apoptosis. Modulator of endoplasmic reticulum stress-mediated programmed cell death. Involved in methyl jasmonate-induced leaf senescence through regulating cytoplasmic calcium level. {ECO:0000269|PubMed:16507080, ECO:0000269|PubMed:18039663, ECO:0000269|PubMed:22563118}.
InductionUp-regulated by water stress, heat-shock, mycotoxin and pathogens. {ECO:0000269|PubMed:16507080, ECO:0000269|PubMed:19674971, ECO:0000269|PubMed:20298483}.
InteractionP59220:CAM7; NbExp=2; IntAct=EBI-1644586, EBI-1236031; O48845:CYTB5-B; NbExp=5; IntAct=EBI-1644586, EBI-2295402;
SimilarityBelongs to the BI1 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:19054355}; Multi-pass membrane protein {ECO:0000269|PubMed:19054355}.
SubunitInteracts (via C-terminus) with calmodulin, CYTB5-B and CYTB5-D. Interacts indirectly with FAH1 via CYTB5-D. {ECO:0000269|PubMed:17142482, ECO:0000269|PubMed:19054355, ECO:0000269|PubMed:19674971, ECO:0000269|PubMed:22635113}.
Tissue SpecificityExpressed in root tips, root vasculature, flower tissues, including stamens and sepals, and in the base of siliques. Not detected in mature leaves. {ECO:0000269|PubMed:19674971}.