LMPD Database

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LMP010018

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein EntryPIS1_ARATH
UniProt IDQ8LBA6
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=400 uM for myo-inositol {ECO:0000269|PubMed:14563413}; KM=10 uM for CDP-diacylglycerol {ECO:0000269|PubMed:14563413};
Catalytic ActivityCDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. {ECO:0000269|PubMed:10411624}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10411624, ECO:0000269|PubMed:10809447}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:10411624, ECO:0000269|PubMed:10809447};
FunctionCatalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:10411624, ECO:0000269|PubMed:10809447, ECO:0000269|PubMed:11985617, ECO:0000269|PubMed:14563413}.
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in stems, flowers, shoots and roots. Present in epidermal tissues. {ECO:0000269|PubMed:10809447}.