LMPD Database

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LMP010139

UniProt Annotations

Entry Information
Gene Namelipoamide dehydrogenase 1
Protein EntryPLPD1_ARATH
UniProt IDA8MS68
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=A8MS68-1; Sequence=Displayed; Name=2; IsoId=A8MS68-2; Sequence=VSP_047927, VSP_047928;
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
Disruption PhenotypeArsenate hypersensitivity. {ECO:0000269|PubMed:20488895}.
FunctionLipoamide dehydrogenase is a component of the plastidial pyruvate dehydrogenase complex (PDC). {ECO:0000269|PubMed:11056213}.
MiscellaneousThe active site is a redox-active disulfide bond. {ECO:0000250}.
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast stroma {ECO:0000269|PubMed:11056213}.
SubunitHomodimer (By similarity). Part of the plastidial pyruvate dehydrogenase complex (PDC) containing multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000250}.
Tissue SpecificityExpressed mainly in flower buds and immature siliques, and to a lesser extend in flowers. {ECO:0000269|PubMed:11056213}.