LMPD Database

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LMP010140

UniProt Annotations

Entry Information
Gene Namedihydrolipoyl dehydrogenase 1
Protein EntryDLDH1_ARATH
UniProt IDQ9M5K3
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
FunctionLipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes. {ECO:0000269|PubMed:11598235}.
InductionUp-regulated by light. {ECO:0000269|PubMed:11598235}.
MiscellaneousThe active site is a redox-active disulfide bond.
PtmS-nytrosylated at unknown positions.
Sequence CautionSequence=AAF79529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14671022}.
SubunitHomodimer (By similarity). Part of both the glycine cleavage system composed of four proteins: P, T, L and H and of the pyruvate dehydrogenase complex containing multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000250}.
Tissue SpecificityPreferentially expressed in leaves, flowers and siliques and at a lower level in roots and stems. {ECO:0000269|PubMed:11598235}.