LMPD Database

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LMP010142

UniProt Annotations

Entry Information
Gene Namedihydrolipoyl dehydrogenase 2
Protein EntryDLDH2_ARATH
UniProt IDQ9M5K2
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9M5K2-1; Sequence=Displayed; Name=2; IsoId=Q9M5K2-2; Sequence=VSP_021588, VSP_021589; Note=May be due to an intron retention. No experimental confirmation available.;
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
Disruption PhenotypeNo visible phenotype, probably due to redundancy with LPD1. {ECO:0000269|PubMed:11598235}.
FunctionLipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes. {ECO:0000269|PubMed:11598235, ECO:0000269|PubMed:14764908}.
MiscellaneousThe active site is a redox-active disulfide bond.
PtmS-nytrosylated at unknown positions.
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:14764908}.
SubunitHomodimer (By similarity). Part of both the glycine cleavage system composed of four proteins: P, T, L and H and of the pyruvate dehydrogenase complex containing multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000250}.
Tissue SpecificityPreferentially expressed in roots, flowers and siliques and at a lower level in stems and leaves. {ECO:0000269|PubMed:11598235}.