LMPD Database

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LMP010147

UniProt Annotations

Entry Information
Gene NameDihydrolipoamide succinyltransferase
Protein EntryODO2B_ARATH
UniProt IDQ8H107
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8H107-1; Sequence=Displayed; Name=2; IsoId=Q8H107-2; Sequence=VSP_039870; Name=3; IsoId=Q8H107-3; Sequence=VSP_039869; Note=May be due to an intron retention. No experimental confirmation available.;
Catalytic ActivitySuccinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250};
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
PathwayAmino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Sequence CautionSequence=AAM67267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AY096643; Type=Frameshift; Positions=207; Evidence={ECO:0000305}; Sequence=CAB36537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB79546.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
SimilarityContains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:14671022}.
SubunitForms a 24-polypeptide structural core with octahedral symmetry. {ECO:0000250}.