LMPD Database

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LMP010349

UniProt Annotations

Entry Information
Gene Namegeranylgeranyl pyrophosphate synthase 1
Protein EntryGGPP1_ARATH
UniProt IDQ0WUL9
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic ActivityDimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic ActivityGeranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
FunctionHeterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit. In vitro, the large subunit catalyzes mainly the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive. Upon association of the two subunits, the product profile changes and the production of gerany-diphosphate is strongly increased. {ECO:0000269|PubMed:19482937}.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
SimilarityBelongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast {ECO:0000269|PubMed:10759500}.
SubunitMonomer. Part of a heterodimeric geranyl(geranyl)diphosphate synthase. Interacts with GGR. {ECO:0000269|PubMed:19482937}.
Tissue SpecificityExpressed ubiquitously. {ECO:0000269|PubMed:10759500}.