LMPD Database

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LMP010419

UniProt Annotations

Entry Information
Gene Nameglycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Protein EntryGPDHC_ARATH
UniProt IDO22216
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activitysn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but mutant plants have increased NADH/NAD(+) ratios, decreased levels of glycerol-3-phosphate, and produce constitutive high levels of reactive oxygen species (ROS). {ECO:0000269|PubMed:16415206}.
FunctionInvolved in cell redox homeostasis. Required for maintaining a steady state cellular NADH/NAD(+) ratio through a mitochondrial glycerol-3-phosphate redox shuttle. May function with the mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase SDP6 to shuttle reducing equivalents into the mitochondria for respiration. {ECO:0000269|PubMed:16415206}.
InductionBy abscisic acid and salt and dehydration treatments. Down-regulated by hypoxia. {ECO:0000269|PubMed:16415206}.
SimilarityBelongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}.
Tissue SpecificityExpressed in roots, leaves, flowers and siliques. {ECO:0000269|PubMed:16415206}.