LMPD Database

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LMP010492

UniProt Annotations

Entry Information
Gene NameHydroxymethylglutaryl-CoA synthase
Protein EntryHMCS_ARATH
UniProt IDP54873
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54873-1; Sequence=Displayed; Name=2; IsoId=P54873-2; Sequence=VSP_008902;
Catalytic ActivityAcetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116, ECO:0000269|PubMed:8566777}.
Disruption PhenotypeDefect in pollen adhesion to the stigma resulting in male sterility under normal growth conditions. {ECO:0000269|PubMed:20484369}.
FunctionThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation. {ECO:0000269|PubMed:20484369}.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
SimilarityBelongs to the HMG-CoA synthase family. {ECO:0000305}.
Tissue SpecificityHighly expressed in flower buds, pollen grains and anthers in the tapetal cells, at an intermediate levels in roots and weakly in leaves. {ECO:0000269|PubMed:20484369}.