LMPD Database

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LMP010566

UniProt Annotations

Entry Information
Gene Namelong-chain acyl-CoA synthetase 6
Protein EntryLACS6_ARATH
UniProt IDQ8LPS1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:12177484, ECO:0000269|PubMed:12366803}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental StageInduced during seed germination. {ECO:0000269|PubMed:12366803}.
Disruption PhenotypeSeedlings of the lacs6 and lacs7 double mutant were arrested in postgerminative growth due to inability to mobilize fatty acids into beta-oxidation, a necessary process to pursue the development. {ECO:0000269|PubMed:14742880}.
FunctionActivation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Might play a regulatory role both in fatty acid import into glyoxysomes and in fatty acid beta-oxidation. Displays redundant function with LACS7 into the seed development process. {ECO:0000269|PubMed:12481085, ECO:0000269|PubMed:14742880}.
InductionUp-regulated by ozone. {ECO:0000269|PubMed:16256065}.
PathwayLipid metabolism; fatty acid metabolism.
Sequence CautionSequence=AAF23219.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:12366803, ECO:0000269|PubMed:12481085}. Glyoxysome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityPreferentially expressed in seeds and senescent leaves. {ECO:0000269|PubMed:16256065}.