LMPD Database

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LMP010571

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase subunit LCB2
Protein EntryLCB2A_ARATH
UniProt IDQ9LSZ9
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Developmental StageDetected at high levels in the petiole, sepals and petals in young flowers, but was not detected in the anthers during the early stages of pollen development. {ECO:0000269|PubMed:18208516}.
Disruption PhenotypeNo visible phenotype. Lcb2a and lcb2b double mutant is not viable due to pollen lethality. {ECO:0000269|PubMed:18208516}.
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB1 constitutes the catalytic core. Involved in the regulation of the programmed cell death (PCD) signaling pathway. Plays an important role during male gametogenesis and embryogenesis. {ECO:0000269|PubMed:11726713, ECO:0000269|PubMed:18208516, ECO:0000269|PubMed:21534970}.
MiscellaneousThe lcb2a-1 mutant is incapable of initiating programmed cell death (PCD) after induction by fumonisin B1 (FB1), a specific inhibitor of ceramide synthase.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:11726713}; Single-pass membrane protein {ECO:0000269|PubMed:11726713}.
SubunitHeterodimer with LCB1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 (LCB2a or LCB2b). {ECO:0000269|PubMed:17194770, ECO:0000269|PubMed:18208516}.
Tissue SpecificityUbiquitous. Detected in leaves, roots, stems, flowers and at a lower level in mature seeds. {ECO:0000269|PubMed:11171191, ECO:0000269|PubMed:11726713, ECO:0000269|PubMed:18208516}.