LMPD Database

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LMP010572

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase 1
Protein EntryLCB2B_ARATH
UniProt IDQ9M304
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Developmental StageIn young flower buds was initially restricted to developing pollen spores within the stamen and is not detected in the petals, glumes or petiole until the flowers are mature. {ECO:0000269|PubMed:18208516}.
Disruption PhenotypeNo visible phenotype. Lcb2a and lcb2b double mutant is not viable due to pollen lethality. {ECO:0000269|PubMed:18208516}.
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB1 constitutes the catalytic core. Plays an important role during male gametogenesis and embryogenesis. {ECO:0000269|PubMed:18208516}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
SubunitHeterodimer with LCB1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 (LCB2a or LCB2b). {ECO:0000269|PubMed:18208516}.
Tissue SpecificityUbiquitous with the highest expression in flowers. {ECO:0000269|PubMed:18208516}.