LMPD Database

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LMP010587

UniProt Annotations

Entry Information
Gene Namelysophosphatidylcholine acyltransferase 1
Protein EntryMBOA1_ARATH
UniProt IDF4IDU4
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but the double mutants lpcat1 and lpcat2-2 show increased contents of very-long-chain fatty acids and decreased polyunsaturated fatty acids in seed triacylglycerols. {ECO:0000269|PubMed:22233193, ECO:0000269|PubMed:22932756, ECO:0000269|PubMed:23150634}.
FunctionLysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity) Can also utilizes lysophosphatidylglycerol (LPG) as substrate in vitro. Has neither activity towards lysophosphatidic acid (LPA) nor lysophosphatidylinositol (LPI). Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. The primary function of the Lands cycle is to provide a route for acyl remodeling to modify fatty acid (FA) composition of phospholipids derived from the Kennedy pathway. Is involved in PC acyl editing and phosphocholine headgroup exchange between PC and diacylglycerols. This processes control the majority of acyl fluxes through PC to provide polyunsaturated fatty acids for triacylglycerols synthesis in seeds. {ECO:0000269|PubMed:18154737, ECO:0000269|PubMed:22932756, ECO:0000269|PubMed:23150634}.
Sequence CautionSequence=AAF88094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:22923678}; Multi-pass membrane protein {ECO:0000305|PubMed:22923678}.
Tissue SpecificityExpressed in roots, rosette leaves, petals, stigma, chalazal endosperm of developing seeds and vascular bundles of siliques. {ECO:0000269|PubMed:23150634}.