LMPD Database

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LMP010589

UniProt Annotations

Entry Information
Gene Namephospholipid/glycerol acyltransferase family protein
Protein EntryLPCT1_ARATH
UniProt IDQ8L7R3
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.0-9.0. {ECO:0000269|PubMed:19445718};
Catalytic ActivityAcyl-CoA + 1-O-(alk-1-enyl)glycero-3- phosphocholine = CoA + plasmenylcholine. {ECO:0000269|PubMed:19445718}.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
FunctionDisplays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Exhibits strong acylation activity of lysophosphatidylethanolamine (LPE) and lysophosphatidate (LPA), with lower activity on lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Has a preference for 18:1-LPE over 16:0-LPE as acceptor and palmitoyl-CoA (16:0-CoA) as acyl donor. Activity is calcium-independent. {ECO:0000269|PubMed:19445718}.
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=AAF14683.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:16618929, ECO:0000305|PubMed:22923678}; Single-pass membrane protein {ECO:0000305|PubMed:16618929, ECO:0000305|PubMed:22923678}.