LMPD Database

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LMP010590

UniProt Annotations

Entry Information
Gene Namecalcineurin B subunit-related protein
Protein EntryLPCT2_ARATH
UniProt IDQ8S8S2
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8S8S2-1; Sequence=Displayed; Name=2; IsoId=Q8S8S2-2; Sequence=VSP_046521, VSP_046522; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Biophysicochemical PropertiespH dependence: Optimum pH is 9.0. {ECO:0000269|PubMed:19445718};
Catalytic ActivityAcyl-CoA + 1-O-(alk-1-enyl)glycero-3- phosphocholine = CoA + plasmenylcholine. {ECO:0000269|PubMed:19445718}.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
FunctionDisplays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Exhibits strong acylation activity of lysophosphatidylethanolamine (LPE) and lower activity on lysophosphatidate (LPA). Has a preference for 18:1-LPE over 16:0- LPE as acceptor and palmitoyl-CoA (16:0-CoA) as acyl donor. Activity is calcium-independent. {ECO:0000269|PubMed:19445718}.
MiscellaneousThe ratio of isoform 2/isoform 1 mRNA is increased about 15-fold in the nonsense mRNA reducing factor mutant upf3-1. {ECO:0000305|PubMed:16098107}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
SimilarityContains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.