LMPD Database

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LMP010617

UniProt Annotations

Entry Information
Gene Namemethylcrotonoyl-CoA carboxylase beta chain
Protein EntryMCCB_ARATH
UniProt IDQ9LDD8
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA.
FunctionCarboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000250}.
MiscellaneousTemporal and spatial accumulation of the alpha and beta subunits during development at approximately equal molar ratios.
PathwayAmino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
Sequence CautionSequence=CAA17569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA19885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the AccD/PCCB family. {ECO:0000305}.
SimilarityContains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitProbably a heterodimer composed of biotin-containing alpha subunits and beta subunits. {ECO:0000250}.
Tissue SpecificityIn roots, cotyledons, leaves, flowers, ovaries, siliques and embryos.