LMPD Database

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LMP010618

UniProt Annotations

Entry Information
Gene Namemethylcrotonoyl-CoA carboxylase subunit alpha
Protein EntryMCCA_ARATH
UniProt IDQ42523
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q42523-1; Sequence=Displayed; Name=2; IsoId=Q42523-2; Sequence=VSP_008910; Note=May be due to exon skipping. No experimental confirmation available.;
Catalytic ActivityATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA.
CofactorName=biotin; Xref=ChEBI:CHEBI:57586; Note=Biotin.;
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
FunctionBiotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000250}.
MiscellaneousTemporal and spatial accumulation of the alpha and beta subunits during development at approximately equal molar ratios.
PathwayAmino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
Sequence CautionSequence=AAD25800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
SimilarityContains 1 biotin carboxylation domain. {ECO:0000305}.
SimilarityContains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitProbably a heterodimer composed of biotin-containing alpha subunits and beta subunits. {ECO:0000250}.
Tissue SpecificityIn roots, cotyledons, leaves, flowers, ovaries, siliques and embryos. {ECO:0000269|PubMed:10681539}.