LMPD Database

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LMP010730

UniProt Annotations

Entry Information
Gene NamePAP-specific phosphatase HAL2-like protein
Protein EntryDPNPH_ARATH
UniProt IDQ38945
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme RegulationInhibited by Li(+) (IC(50)=10 millimolar), Na(+) (IC(50)=50 millimolar) and Ca(2+) (IC(50)=0.06 millimolar).
FunctionConverts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation. {ECO:0000250, ECO:0000269|PubMed:10205895}.
MiscellaneousSubstrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) > adenosine 3'-phosphate 5'-phosphosulfate (PAPS). No activity observed against 3' or 5'-AMP, inositol mono and diphosphates and fructose-1,6-bisphosphate.
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
Tissue SpecificityExpressed in roots, leaves, stems, flowers and siliques.