LMPD Database

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LMP010757

UniProt Annotations

Entry Information
Gene Namefatty acid beta-oxidation multifunctional protein AIM1
Protein EntryAIM1_ARATH
UniProt IDQ9ZPI6
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=115 uM for crotonyl-CoA {ECO:0000269|PubMed:10521521};
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic Activity(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Catalytic Activity(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Catalytic Activity(S)-3-hydroxybutanoyl-CoA = (R)-3- hydroxybutanoyl-CoA.
Disruption PhenotypeReduced rosette size, twisted leaves, and abnormal and sterile flowers. {ECO:0000269|PubMed:10521521}.
DomainThe epimerase and isomerase activities are contained in the N-terminal region while the dehydrogenase activity is in the C-terminal region. {ECO:0000250}.
FunctionInvolved in peroxisomal fatty acid beta-oxidation. Required for wound-induced jasmonate biosynthesis. Possesses enoyl-CoA hydratase activity against short chain substrates (C4- C6) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C16). {ECO:0000269|PubMed:10521521, ECO:0000269|PubMed:17544464, ECO:0000269|PubMed:20463021}.
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityIn the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000305}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10521521}.