LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP010786

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-kinase alpha
Protein EntryP4KA1_ARATH
UniProt IDQ9SXA1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Disruption PhenotypeLethal. {ECO:0000269|PubMed:22318862}.
Enzyme RegulationRepressed by PtdIns4P, adenosine and wortmannin, but stimulated by other negatively charged lipids such as PtdIns3P, PtdOH, and phosphatidyl-serine (PtdSer). {ECO:0000269|PubMed:12805633}.
FunctionActs on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Can bind to phosphatidylinositol 4- monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5- bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3-phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI- PLC) pathway. {ECO:0000269|PubMed:22318862, ECO:0000269|PubMed:9712908}.
Sequence CautionSequence=AAD43164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationMembrane {ECO:0000269|PubMed:12805633}; Peripheral membrane protein {ECO:0000269|PubMed:12805633}; Cytoplasmic side {ECO:0000269|PubMed:12805633}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12805633}.
SubunitInteracts in vitro with actin filaments via its PH domain. {ECO:0000269|PubMed:12805633}.
Tissue SpecificityPresent in leaves and inflorescences. {ECO:0000269|PubMed:9712908}.