LMPD Database

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LMP010787

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-OH kinase beta1
Protein EntryP4KB1_ARATH
UniProt IDQ9FMJ0
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Disruption PhenotypeWhen associated with PI4KB2 disruption: aberrant root hair morphologies, and short and wavy pollen tubes. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902}.
DomainThe PPC (Plant PI4K Charged) region is involved in membrane targeting and phospholipid binding. {ECO:0000269|PubMed:16649109}.
Enzyme RegulationStimulated by phosphatidylinositol 4-phosphate (PtdIns4P). Slightly repressed by phosphatidyl-choline (PtdCho), wortmannin and adenosine. {ECO:0000269|PubMed:10026194, ECO:0000269|PubMed:12805633}.
FunctionActs on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. {ECO:0000269|PubMed:10026194, ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902, ECO:0000269|PubMed:20603382, ECO:0000269|PubMed:21134079, ECO:0000269|PubMed:22318862}.
InteractionQ9C5U2:AHK2; NbExp=2; IntAct=EBI-1807432, EBI-1100634;
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationCell membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to tip-localized membranes in growing root hairs.
SubunitInteracts with AHK2, CBL1 and RABA4D. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:18642946, ECO:0000269|PubMed:19208902}.
Tissue SpecificityExpressed constitutively in leaves, roots, flowers, and stems. {ECO:0000269|PubMed:10026194}.