LMPD Database

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LMP010788

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-OH kinase beta2
Protein EntryP4KB2_ARATH
UniProt IDQ0WPX9
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Disruption PhenotypeWhen associated with PI4KB1 disruption: aberrant root hair morphologies, and short and wavy pollen tubes. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902}.
DomainThe PPC (Plant PI4K Charged) region is involved in membrane targeting and phospholipid binding. {ECO:0000250}.
FunctionActs on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate (By similarity). Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB1, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB1 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. {ECO:0000250, ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902, ECO:0000269|PubMed:21134079, ECO:0000269|PubMed:22318862}.
Sequence CautionSequence=CAC05461.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationCell membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.