LMPD Database

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LMP010828

UniProt Annotations

Entry Information
Gene Namephospholipid N-methyltransferase
Protein EntryPLMT_ARATH
UniProt IDQ9SAH5
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine.
Disruption PhenotypeNo visible phenotype under normal growth conditions. {ECO:0000269|PubMed:19366698}.
FunctionCatalyzes the S-adenosylmethionine-dependent methylation of ethanolamine-containing phospholipids to produce the abundant membrane lipid phosphatidylcholine (PtdCho). However, in a heterologous yeast expression system, Arabidopsis and soybean PLMTs methylate phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine but cannot utilize phosphatidylethanolamine as a substrate. {ECO:0000269|PubMed:19366698}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis.
Sequence CautionSequence=BAC43303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.