LMPD Database

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LMP010852

UniProt Annotations

Entry Information
Gene Namephosphoinositide phospholipase C8
Protein EntryPLCD8_ARATH
UniProt IDQ9STZ3
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CautionContains substitutions of several amino acids thought to be essential for catalytic activity. Its enzyme activity is therefore unsure. {ECO:0000305}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000250}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular LocationCell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityExpressed in leaves, roots, flowers and siliques. {ECO:0000269|Ref.6}.