LMPD Database

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LMP010988

UniProt Annotations

Entry Information
Gene Namemyo-inositol-1-phosphate synthase
Protein EntryINO3_ARATH
UniProt IDQ9LX12
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.31 mM for D-glucose 6-phosphate {ECO:0000269|PubMed:20215587}; KM=0.13 uM for NAD(+) {ECO:0000269|PubMed:20215587}; Note=kcat is 5.2 min(-1) for D-glucose 6-phosphate. kcat is 4.8 min(-1) for NAD(+).;
Catalytic ActivityD-glucose 6-phosphate = 1D-myo-inositol 3- phosphate. {ECO:0000269|PubMed:20215587}.
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540;
Disruption PhenotypeLethal when homozygous. {ECO:0000269|PubMed:19812700}.
FunctionInvolved in myo-inositol synthesis. {ECO:0000269|PubMed:20215587}.
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
SimilarityBelongs to the myo-inositol 1-phosphate synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:18603618, ECO:0000269|PubMed:20215587}.
Tissue SpecificityExpressed in siliques, leaves, roots, seed endosperm, but not in embryos. Highest expression in roots. Confined to vascular tissue and hydathodes of leaves. {ECO:0000269|PubMed:18603618, ECO:0000269|PubMed:20215587}.