LMPD Database

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LMP011097

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase subunit beta
Protein EntryFNTB_ARATH
UniProt IDQ38920
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=5.4 uM for CVIM substrate {ECO:0000269|PubMed:20565889}; KM=5.5 uM for CVIQ substrate {ECO:0000269|PubMed:20565889}; KM=6.9 uM for CVII substrate {ECO:0000269|PubMed:20565889}; KM=7.0 uM for CVIL substrate {ECO:0000269|PubMed:20565889}; Note=Kcat is 49.1 h(-1), 28.8 h(-1), 12.8 h(-1) and 3.7 h(-1) for CVIQ, CVIM, CVII and CVIL substrates, respectively.;
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20565889}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:20565889};
Disruption PhenotypePlants show an increase in floral organ number, particularly in the sepals and petals, correlating with an increase in the width of young floral meristems. {ECO:0000269|PubMed:10840062}.
FunctionCatalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X (CaaX). The beta subunit is responsible for peptide-binding. {ECO:0000269|PubMed:20565889}.
InteractionQ9LX33:FTA; NbExp=4; IntAct=EBI-1553332, EBI-1553317;
Sequence CautionSequence=BAB10909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 5 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of FTA and FTB (farnesyltransferase). Heterodimer of an alpha and a beta subunit. {ECO:0000269|PubMed:20565889}.