LMPD Database

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LMP011226

UniProt Annotations

Entry Information
Gene Namepyruvate dehydrogenase complex E1 alpha subunit
Protein EntryODPA1_ARATH
UniProt IDP52901
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Enzyme RegulationE1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit. {ECO:0000250}.
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14671022}.
SubunitTetramer of 2 alpha and 2 beta subunits. {ECO:0000250}.
Tissue SpecificityExpressed in roots, rosettes and flowers. {ECO:0000269|PubMed:7590338}.