LMPD Database

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LMP011228

UniProt Annotations

Entry Information
Gene Namepyruvate dehydrogenase E1 alpha subunit
Protein EntryODPA3_ARATH
UniProt IDO24457
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAF26472.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g01080 and At1g01090.; Evidence={ECO:0000305};
Subcellular LocationPlastid, chloroplast {ECO:0000305}.
SubunitTetramer of 2 alpha and 2 beta subunits. {ECO:0000250}.