LMPD Database

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LMP011251

UniProt Annotations

Entry Information
Gene Name["bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase"]
Protein EntryDPNP1_ARATH
UniProt IDQ42546
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D- myo-inositol 4-phosphate + phosphate.
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationInhibited by Li(+) (IC(50)=0.20 millimolar) and Na(+) (IC(50)=200 millimolar).
FunctionConverts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing. {ECO:0000269|PubMed:11485991, ECO:0000269|PubMed:17993620, ECO:0000269|PubMed:8721754}.
MiscellaneousMutation in the FRY1 gene results in super- induction of abscisic acid (ABA)- and stress-responsive genes, due to inositol 1,4,5-trisphosphate (IP3) accumulation.
MiscellaneousSubstrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) = adenosine 3'-phosphate 5'-phosphosulfate (PAPS)> inositol 1,4-bisphosphate >> inositol 1,4,5-trisphosphate. No activity observed against 3' or 5'-AMP, inositol monophosphate and fructose-1,6-bisphosphate.
PathwaySignal transduction; phosphatidylinositol signaling pathway.
Sequence CautionSequence=AED97825.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
Tissue SpecificityExpressed in roots, leaves, stems, flowers and siliques. {ECO:0000269|PubMed:10205895, ECO:0000269|PubMed:11485991}.