LMPD Database

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LMP011252

UniProt Annotations

Entry Information
Gene Name["3'(2'),5'-bisphosphate nucleotidase"]
Protein EntryDPNP2_ARATH
UniProt IDO49623
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D- myo-inositol 4-phosphate + phosphate.
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationInhibited by Li(+) (IC(50)=10 millimolar), Na(+) (IC(50)=200 millimolar) and Ca(2+) (IC(50)=0.03 millimolar).
FunctionConverts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation. Is also able to hydrolyze inositol 1,4-bisphosphate. {ECO:0000250, ECO:0000269|PubMed:10205895}.
MiscellaneousSubstrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) > adenosine 3'-phosphate 5'-phosphosulfate (PAPS)>> inositol 1,4-bisphosphate. No activity observed against 3' or 5'-AMP, inositol monophosphate and fructose-1,6- bisphosphate.
PathwaySignal transduction; phosphatidylinositol signaling pathway.
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
Tissue SpecificityVery low expression in roots, leaves, stems, flowers and siliques.