LMPD Database

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LMP011291

UniProt Annotations

Entry Information
Gene Namegeranyl diphosphate synthase 1
Protein EntrySPS3_ARATH
UniProt IDQ5HZ00
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5HZ00-1; Sequence=Displayed; Name=2; IsoId=Q5HZ00-2; Sequence=VSP_042136; Note=No experimental confirmation available.; Name=3; IsoId=Q5HZ00-3; Sequence=VSP_042135; Note=Derived from EST data. No experimental confirmation available.;
Catalytic ActivityGeranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate. {ECO:0000269|PubMed:21220764}.
CautionWas proposed to be a geranyl diphosphate synthase involved in gibberellins biosynthesis. {ECO:0000305|PubMed:11069698}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Disruption PhenotypeEmbryo lethal. {ECO:0000269|PubMed:17877699, ECO:0000269|PubMed:21950843}.
FunctionMay be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate. {ECO:0000269|PubMed:11069698, ECO:0000269|PubMed:17877699, ECO:0000269|PubMed:21220764, ECO:0000269|PubMed:21950843}.
MiscellaneousSilencing of At2g34630 decreases ubiquinone-9 biosynthesis in mitochondria but has no effect on plastoquinone-9 biosynthesis in chloroplast, maybe due to the redundancy with At1g17050.
Sequence CautionSequence=AAC26705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast. Mitochondrion.
SubunitHomodimer. {ECO:0000269|PubMed:21220764}.
Tissue SpecificityUbiquitous. Highest expression in seeds and shoot apical meristem. {ECO:0000269|PubMed:21950843}.